BSEP (ABCB11)
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BSEP Transporter: ABCB11
About BSEP
The BSEP transporter is encoded by the ABCB11 gene. It is also known as the bile salt export pump. BSEP is expressed in liver hepatocytes on the apical side of the bile canalicular membrane. It serves to pump bile salts and from the liver into bile.
BSEP Substrates
BSEP substrates include bile salts such as taurocholate.
BSEP Inhibitors
BSEP inhibitors include natural bile salts and xenobiotics such as rifampicin.
Optivia BSEP Transporter Assays
Optivia offers BSEP substrate and inhibition assays in vesicles. We offer a wide range of studies including single concentration screens up to full kinetic studies to determine the IC50 for BSEP inhibitors and Vmax, Km and/or IC50 for BSEP substrates.
The probe substrate for the Optivia BSEP assay is taurocholate. Rifampicin is the reference inhibitor. These serve as the positive controls for the BSEP substrate assays and the BSEP inhibition assays, respectively.
About BSEP
The BSEP transporter is encoded by the ABCB11 gene. It is also known as the bile salt export pump. BSEP is expressed in liver hepatocytes on the apical side of the bile canalicular membrane. It serves to pump bile salts and from the liver into bile.
BSEP Substrates
BSEP substrates include bile salts such as taurocholate.
BSEP Inhibitors
BSEP inhibitors include natural bile salts and xenobiotics such as rifampicin.
Optivia BSEP Transporter Assays
Optivia offers BSEP substrate and inhibition assays in vesicles. We offer a wide range of studies including single concentration screens up to full kinetic studies to determine the IC50 for BSEP inhibitors and Vmax, Km and/or IC50 for BSEP substrates.
The probe substrate for the Optivia BSEP assay is taurocholate. Rifampicin is the reference inhibitor. These serve as the positive controls for the BSEP substrate assays and the BSEP inhibition assays, respectively.