Transporter Proteins
FREE ROAD MAP TO FDA WHITE-PAPER
The ITC Transporter White Paper provides detailed guidance for transporter mediated DDI studies for the seven transporters recommended in the March 17, 2010 FDA Advisory Committee vote. Get the White Paper and a Road Map Summary to help navigate it.
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About Transporters
A selection of common transporters that can effect drug safety and efficacy
(Image courtesy of influence by Pär Matsson PhD, Uppsala University, Sweden)
Transporters are transmembrane proteins that act as nature’s gatekeeper for cellular entry and exit by facilitating the movement of substances (drugs and endogenous compounds such as hormones and neurotransmitters) across cell and organ membranes. Transporters can mediate drug disposition and control drug levels because they are expressed differentially in various tissues and organs.
Inhibition or activation of a transporter that serves a role in the absorption, disposition, metabolism, elimination (ADME) and toxicity (ADMET) of a drug can have profound clinical effects ranging from lowering drug efficacy to compromising safety, including drug-drug interactions (DDIs).
There are more than 400 currently known unique human transporters, and the body of evidence is growing rapidly for their role in DDI, ADMET and early drug discovery.
A selection of common transporters that can effect drug safety and efficacy
(Image courtesy of influence by Pär Matsson PhD, Uppsala University, Sweden)
Transporters are transmembrane proteins that act as nature’s gatekeeper for cellular entry and exit by facilitating the movement of substances (drugs and endogenous compounds such as hormones and neurotransmitters) across cell and organ membranes. Transporters can mediate drug disposition and control drug levels because they are expressed differentially in various tissues and organs.
Inhibition or activation of a transporter that serves a role in the absorption, disposition, metabolism, elimination (ADME) and toxicity (ADMET) of a drug can have profound clinical effects ranging from lowering drug efficacy to compromising safety, including drug-drug interactions (DDIs).
There are more than 400 currently known unique human transporters, and the body of evidence is growing rapidly for their role in DDI, ADMET and early drug discovery.